Posts

Tangram: Stitching the Cellular Map Back Together

The Tangram algorithm uses deep learning to align dissociated single-cell RNA-seq data onto spatial transcriptomics data, enabling …
Oct 29, 2021 6 min read Computational Methods

The Blueprint for Causal Biology: CROP-seq Links Gene to Function at Scale

Datlinger et al. introduce CROP-seq, a method that captures both a CRISPR guide RNA and its resulting single-cell transcriptome, …
Feb 4, 2021 5 min read Computational Methods

Perturb-Seq: Moving from 'What Is' to 'What If' in a Single Experiment

Perturb-seq combines pooled CRISPR screens with single-cell transcriptomics to systematically link genetic perturbations to their …
Feb 3, 2021 6 min read Omics Sequencing

Busting the Myth of the scRNA-seq "Dropout"

This analysis elegantly demonstrates that the high number of zeros in droplet-based scRNA-seq is not a technical artifact but is …
Jan 20, 2020 5 min read Computational Methods

Run EPIC

The EPIC toolkit was initially published here: Hu, L. Z., et al. “EPIC: software toolkit for elution profile-based inference of …
Dec 12, 2019 2 min read Software, Publication

Statistical Modelling of AP-MS Data (SMAD)

This R package implements statistical modelling of affinity purification–mass spectrometry (AP-MS) data to compute confidence scores to …
May 22, 2019 2 min read Software

Awsome affinity purification mass spectrometry (AP-MS)

A collection of resources regarding affinity purification mass spectrometry proteomics for the identification of protein-protein …
Jul 8, 2018 2 min read Awsome

Hello, RGED!

Jul 23, 2014 1 min read Database, Publication